Species

GeneNetwork (GN) contains data from different groups of mice. The BXD genetic reference panel (GRP) will be your best bet if you are just exploring GN. All groups must have a genotype data set (under Type) and most also have a phenotpe data set (also under Type). Phenotype in this case usually means classical trait data that we have gathered from various publications. Molecular expression data, when available, are listed with the suffix "mRNA."

Here are the groups to select for access to particular types of data:

• AKXD: Expression data for mammary tumors generated by Kent Hunter at NCI.
• AXB/BXA: Classical phenotypes that have usualy been collected from the literature.
• B6BTBRF2: Expression data for liver generated by Alan Attie and colleagues.
• B6D2F2: Expression data for whole brain generated by Robert Hitzemann and colleagues.
• BDF2-2005: Expression data for striatum generated by Robert Hitzemann and colleagues. The striatum is a large forebrain region involved in learning and movement control that is severely affected in Huntington's and Parkinson's diseases.
• BXD: Expression data for brain and several brain regions, including the cerebellum, hippocampus, and striatum. BXD expression data for whole eye, liver, and hematopoietic stem cells. Classical phenotypes that have usualy been collected from the literature.
• BHF2: F2 cross of BXH. Expression data for adipose, brain, liver, and muscle tissue generated by Jake Lusis at UCLA and Eric Schadt at Rosetta.
• BXH: Only classical phenotypes that have usually been collected from the literature.
• CXB: Expression data for the hippocampus; a brain region involved in learning and memory, epilepsy, and neurodegenerative diseases. Classical phenotypes have also been collected from the literature.
• Heterogeneous Stock (HS) mice: Three expression data sets for hippocampus, lung, and liver are currently available. Phenotype and genotype data are also available at http://gscan.well.ox.ac.uk/.
• LXS: Phenotypes that have usually been generated by investigators at the Institute of Behavior Genetics and at the University of Tennessee over the last few years. We expect the addition of several large brain expression data sets late in 2006.
• MDP: The great majority of data on the Mouse Diversity Panel is taken from the Phenome Project. Unlike the PHone Project, the MDP also includes limited data from the older literature. If you would like to add phenotypes, please submit your data to RW Williams and colleagues.