B6C3HF2(APOE-) UCLA Metabolism


Information on array platform GEO GPL2510.

This June 2005 data freeze provides an estimate of mRNA expression in (adult) brains of F2 intercross mice (C57BL/6J x C3H/HeJ) on ApoE null backgrounds, measured using Agilent microarray pairs. Data were generated at The University of California Los Angeles (UCLA), by Jake Lusis and Thomas Drake. Data were processed using mlratio method developed by He and colleagues (2003 -- Paper with He and Schadt).

The (C57BL/6J X C3H/HeJ)F2 intercross consists of 334 animals of both sexes. All are ApoE null and received a high-fat "Western" diet from 8-24 weeks of age. These have been genotyped for QTL mapping, and various phenotypes measured.

For more information contact Leslie Ingram or Jake Lusis at UCLA.