HBTRC-MLC Human Prefrontal Cortex Agilent HD (Jun11) mlratio

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This study aims at identifying functional variation in the human genome (especially as it pertains to brain expressed RNAs) and elucidate its relationship to disease and drug response. The ~800 individuals in this dataset are composed of approximately 400 Alzheimers disease (AD) cases, 230 Huntington's Disease (HD) and 170 controls (N) matched for age, gender, and post mortem interval (PMI). The tissue specimens for this study were provided by Harvard Brain Tissue Resource Center (HBTRC). Three brain regions (cerebellum, visual cortex, and dorsolateral prefrontal cortex) from the same individuals were profiled on a custom-made Agilent 44K microarray of 39,280 DNA probes uniquely targeting 37,585 known and predicted genes, including splice variants, miRNAs and high-confidence non-coding RNA sequences. The individuals were genotyped on two different platforms, the Illumina HumanHap650Y array and a custom Perlegen 300K array (a focused panel for detection of singleton SNPs). Clinical outcomes available include age at onset, age at death, Braak scores (AD), Vonsattel scores (HD), Regional brain enlargement/atrophy.

Experiment design

See PMID: 25080494

About cases

This data packet contains genotypes, clinical traits, as well as expression traits measured in three regions of the brain: visual cortex, cerebellum, prefrontal cortex. Samples were collected from 803 participants including 388 diagnosed with Alzheimer's disease and 220 diagnosed with Huntington's disease. Genotypes were run using two platforms (Illumina and Perlagen). Expression traits were profiled using a custom Agilent platform. Western-IRB has confirmed that this dataset residing in Sage Bionetworks Repository is 'exempt' under federal regulation 45 CFR 46.101(b)4 and does not involve human subject research as defined by OHRP guidelines.





Series Cerebellum in GN Condition Gender BioSample Name
1 HB_029_N N NA 3405_VC_N_0859
2 HB_058_N N NA 4021_VC_N_0854
3 HB_064_N N NA 4338_VC_N_0861
4 HB_086_N N NA 4729_PF_N_0756
5 HB_091_N N NA 4741_VC_N_0864
6 HB_092_N N NA 4744_VC_N_0865
7 HB_102_N N NA 4810_VC_N_0869
8 HB_119_N N NA 4872_VC_N_0878
9 HB_147_N N NA 5021_VC_N_0852
10 HB_161_N N NA 5077_VC_N_0851
11 HB_162_N N NA 5081_VC_N_1021
12 HB_166_N N NA 5095_VC_N_1024
13 HB_183_N N NA 5162_VC_N_0850
14 HB_206_N N NA 5245_VC_N_0849
15 HB_215_N N NA 5270_VC_N_0848
16 HB_218_N N NA 5276_CR_N_0912
17 HB_223_N N NA 5287_VC_N_0916
18 HB_226_N N NA 5294_VC_N_0919
19 HB_241_N N NA 5326_CR_N_0652
20 HB_243_N N NA 5333_VC_N_1262
21 HB_247_N N NA 5341_VC_N_0923
22 HB_257_N N NA 5368_PF_N_1032
23 HB_264_N N NA 5384_VC_N_0924
24 HB_295_N N NA 5452_VC_N_1268
25 HB_300_N N NA 5463_VC_N_0845
26 HB_311_N N NA 5489_CR_N_0942
27 HB_324_N N NA 5531_VC_N_0844
28 HB_332_N N NA 5547_VC_N_0843
29 HB_340_N N NA 5568_VC_N_0842
30 HB_360_N N NA 5619_CR_N_0645
31 HB_365_N N NA 5632_VC_N_0838
32 HB_367_N N NA 5637_VC_N_0837
33 HB_382_N N NA 5684_PF_N_1270
34 HB_396_N N NA 5718_VC_N_0956
35 HB_398_N N NA 5722_VC_N_1044
36 HB_400_N N NA 5726_VC_N_0834_Bis
37 HB_403_N N NA 5734_VC_N_0833
38 HB_414_N N NA 5772_VC_N_0832_Bis
39 HB_416_N N NA 5778_CR_N_0962
40 HB_418_N N NA 5789_PF_N_1273
41 HB_421_N N NA 5799_VC_N_1058
42 HB_423_N N NA 5803_VC_N_0966
43 HB_426_N N NA 5806_PF_N_1064
44 HB_427_N N NA 5810_CR_N_0636
45 HB_431_N N NA 5823_VC_N_0829
46 HB_432_N N NA 5826_VC_N_0828
47 HB_433_N N NA 5827_VC_N_0827
48 HB_436_N N NA 5832_PF_N_1145
49 HB_443_N N NA 5852_VC_N_0826
50 HB_446_N N NA 5859_VC_N_0825
51 HB_449_N N NA 5866_VC_N_0824
52 HB_450_N N NA 5867_VC_N_1277
53 HB_453_N N NA 5876_VC_N_0823
54 HB_462_N N NA 5903_VC_N_0822
55 HB_464_N N NA 5905_VC_N_0820
56 HB_468_N N NA 5912_VC_N_1286
57 HB_472_N N NA 5925_VC_N_1289
58 HB_475_N N NA 5936_VC_N_0979
59 HB_476_N N NA 5938_VC_N_0819
60 HB_480_N N NA 5946_VC_N_0985
61 HB_485_N N NA 5959_VC_N_0818
62 HB_486_N N NA 5963_VC_N_0987
63 HB_495_N N NA 5980_VC_N_0989
64 HB_497_N N NA 5985_VC_N_0990
65 HB_500_N N NA 5990_VC_N_0817
66 HB_501_N N NA 5991_VC_N_0816
67 HB_504_N N NA 5996_VC_N_0815
68 HB_505_N N NA 5998_VC_N_0814
69 HB_507_N N NA 6006_VC_N_0813
70 HB_508_N N NA 6007_CR_N_0618
71 HB_509_N N NA 6008_PF_N_1081
72 HB_512_N N NA 6023_PF_N_1155
73 HB_516_N N NA 6030_VC_N_0810
74 HB_519_N N NA 6034_VC_N_0809
75 HB_532_N N NA 6060_VC_N_1292
76 HB_541_N N NA 6092_VC_N_1001
77 HB_542_N N NA 6096_VC_N_0807
78 HB_544_N N NA 6101_CR_N_1161
79 HB_547_N N NA 6110_VC_N_1295
80 HB_551_N N NA 6124_VC_N_0806
81 HB_557_N N NA 6134_PF_N_1297
82 HB_560_N N NA 6142_VC_N_0805
83 HB_569_N N NA 6166_VC_N_0804
84 HB_570_N N NA 6170_VC_N_0803
85 HB_572_N N NA 6172_VC_N_1008
86 HB_577_N N NA 6182_VC_N_1166
87 HB_579_N N NA 6187_CR_N_0607
88 HB_581_N N NA 6191_VC_N_1010
89 HB_584_N N NA 6196_CR_N_0605
90 HB_586_N N NA 6200_VC_N_0799
91 HB_587_N N NA 6206_PF_N_1176
92 HB_589_N N NA 6213_VC_N_0798
93 HB_601_N N NA 6241_VC_N_0796
94 HB_604_N N NA 6260_VC_N_0794
95 HB_609_N N NA 6270_VC_N_0793
96 HB_618_N N NA 6289_VC_N_0791
97 HB_622_N N NA 6310_VC_N_0790
98 HB_625_N N NA 6314_VC_N_0789
99 HB_637_N N NA 6340_VC_N_0786
100 HB_638_N N NA 6341_VC_N_0785
101 HB_640_N N NA 6347_VC_N_0784
102 HB_641_N N NA 6356_VC_N_0783
103 HB_643_N N NA 6363_VC_N_0781
104 HB_644_N N NA 6366_VC_N_0780
105 HB_645_N N NA 6374_VC_N_0779
106 HB_650_N N NA 6384_VC_N_0777
107 HB_651_N N NA 6386_VC_N_0776
108 HB_653_N N NA 6388_VC_N_0775
109 HB_659_N N NA 6406_VC_N_1180
110 HB_662_N N NA 6411_VC_N_0771
111 HB_663_N N NA 6415_VC_N_0770
112 HB_670_N N NA 6436_VC_N_0769
113 HB_687_N N NA 6484_VC_N_0765
114 HB_689_N N NA 6486_VC_N_0764
115 HB_694_N N NA 6500_VC_N_0763
116 HB_697_N N NA 6512_VC_N_0762
117 HB_700_N N NA 6520_VC_N_0761
118 HB_711_N N NA 6543_PF_N_1191
119 HB_714_N N NA 6549_VC_N_1198
120 HB_717_N N NA 6553_PF_N_2284
121 HB_721_N N NA 6560_VC_N_2578
122 HB_726_N N NA 6573_PF_N_2293
123 HB_730_N N NA 6580_VC_N_2306
124 HB_735_N N NA 6588_VC_N_1213
125 HB_737_N N NA 6593_VC_N_1219
126 HB_738_N N NA 6594_VC_N_1222
127 HB_759_N N NA 6645_VC_N_1231
128 HB_764_N N NA 6655_VC_N_1240
129 HB_765_N N NA 6656_VC_N_1243
130 HB_767_N N NA 6661_PF_N_2341
131 HB_770_N N NA 6669_VC_N_1246
132 HB_772_N N NA 6676_PF_N_1248
133 HB_001_HD HD F 2028_CR_H_2282
134 HB_003_HD HD F 2685_PF_H_2212
135 HB_004_HD HD M 2706_CR_H_2432
136 HB_006_HD HD M 2737_VC_H_2194
137 HB_007_HD HD NA 2769_VC_H_2193
138 HB_008_HD HD F 2790_CR_H_1890
139 HB_009_HD HD NA 2879_VC_H_2192
140 HB_010_HD HD M 2960_VC_H_2002
141 HB_011_HD HD F 3053_VC_H_2001
142 HB_012_HD HD F 3128_VC_H_1999
143 HB_014_HD HD F 3149_PF_H_2110
144 HB_015_HD HD F 3150_VC_H_1996
145 HB_016_HD HD F 3177_VC_H_2191
146 HB_017_HD HD NA 3195_VC_H_2190
147 HB_018_HD HD M 3200_VC_H_2189
148 HB_019_HD HD M 3209_VC_H_2188
149 HB_020_HD HD M 3224_VC_H_1994
150 HB_022_HD HD F 3242_PF_H_2105
151 HB_024_HD HD NA 3272_VC_H_2186
152 HB_027_HD HD M 3356_VC_H_2439
153 HB_028_HD HD F 3394_PF_H_2104
154 HB_031_HD HD M 3430_VC_H_1990
155 HB_032_HD HD NA 3444_PF_H_2208
156 HB_034_HD HD F 3482_VC_H_1987
157 HB_036_HD HD M 3576_VC_H_1984
158 HB_037_HD HD F 3579_VC_H_1983
159 HB_038_HD HD F 3584_VC_H_2183
160 HB_039_HD HD NA 3635_VC_H_2182
161 HB_041_HD HD F 3695_CR_H_2267
162 HB_042_HD HD M 3697_VC_H_1982
163 HB_043_HD HD NA 3703_VC_H_2180
164 HB_044_HD HD NA 3723_VC_H_2179
165 HB_046_HD HD F 3735_VC_H_1981
166 HB_050_HD HD M 3820_PF_H_2207
167 HB_051_HD HD F 3849_CR_H_2262
168 HB_054_HD HD M 3884_VC_H_2175
169 HB_056_HD HD NA 4012_VC_H_2174
170 HB_057_HD HD NA 4013_VC_H_2173
171 HB_059_HD HD NA 4066_VC_H_2172
172 HB_060_HD HD NA 4094_VC_H_2171
173 HB_061_HD HD F 4116_VC_H_2170
174 HB_062_HD HD NA 4121_VC_H_2169
175 HB_063_HD HD NA 4215_VC_H_2167
176 HB_065_HD HD M 4340_PF_H_2091
177 HB_066_HD HD F 4344_VC_H_1977
178 HB_067_HD HD M 4346_VC_H_2165
179 HB_069_HD HD F 4356_VC_H_2164
180 HB_070_HD HD NA 4386_CR_H_2249
181 HB_072_HD HD NA 4404_VC_H_2161
182 HB_073_HD HD F 4411_VC_H_1975
183 HB_074_HD HD NA 4430_VC_H_2465
184 HB_075_HD HD M 4470_VC_H_1974
185 HB_076_HD HD F 4497_CR_H_1860
186 HB_077_HD HD M 4509_CR_H_2244
187 HB_079_HD HD M 4631_VC_H_1971
188 HB_080_HD HD F 4653_PF_H_2083
189 HB_081_HD HD NA 4678_CR_H_2242
190 HB_084_HD HD M 4718_VC_H_2125
191 HB_090_HD HD NA 4740_CR_H_2474
192 HB_094_HD HD NA 4754_CR_H_2476
193 HB_098_HD HD NA 4780_VC_H_2151
194 HB_101_HD HD F 4809_VC_H_2148
195 HB_105_HD HD NA 4819_CR_H_2238
196 HB_106_HD HD F 4822_VC_H_1969
197 HB_108_HD HD M 4826_VC_H_1968
198 HB_109_HD HD M 4828_VC_H_2124
199 HB_115_HD HD NA 4855_CR_H_2235
200 HB_121_HD HD F 4902_VC_H_1967
201 HB_129_HD HD NA 4938_VC_H_1966
202 HB_141_HD HD F 4996_PF_H_2076
203 HB_152_HD HD NA 5034_CR_H_2233
204 HB_153_HD HD M 5043_VC_H_1960
205 HB_159_HD HD M 5062_VC_H_1959
206 HB_172_HD HD F 5114_PF_H_2070
207 HB_175_HD HD M 5127_PF_H_2068
208 HB_180_HD HD M 5148_VC_H_1944
209 HB_185_HD HD F 5167_CR_H_2231
210 HB_188_HD HD F 5172_VC_H_1951
211 HB_191_HD HD M 5180_VC_H_1949
212 HB_196_HD HD NA 5199_PF_H_2202
213 HB_203_HD HD F 5228_PF_H_2059
214 HB_207_HD HD NA 5248_PF_H_2201
215 HB_228_HD HD F 5299_CR_H_2228
216 HB_233_HD HD M 5312_VC_H_1938
217 HB_235_HD HD F 5316_VC_H_1937
218 HB_242_HD HD F 5328_PF_H_2048
219 HB_266_HD HD M 5387_VC_H_1928
220 HB_271_HD HD M 5394_PF_H_2039
221 HB_272_HD HD F 5396_VC_H_1925
222 HB_279_HD HD F 5409_VC_H_1924
223 HB_294_HD HD M 5448_VC_H_1921
224 HB_301_HD HD NA 5464_VC_H_1919
225 HB_304_HD HD F 5471_VC_H_1918
226 HB_321_HD HD NA 5522_PF_H_2199
227 HB_361_HD HD F 5622_VC_H_2121
228 HB_370_HD HD M 5645_VC_H_1904
229 HB_371_HD HD F 5648_PF_H_2016
230 HB_384_HD HD F 5688_PF_H_2012
231 HB_390_HD HD M 5704_PF_H_2009
232 HB_393_HD HD F 5709_VC_H_1895
233 HB_402_HD HD F 5732_PF_H_2007
234 HB_405_HD HD NA 5742_PF_H_2006
235 HB_407_HD HD M 5745_PF_H_2005
236 HB_408_HD HD M 5747_VC_H_1891
237 HB_415_HD HD NA 5777_PF_H_1551
238 HB_417_HD HD M 5784_PF_H_1554
239 HB_424_HD HD M 5804_VC_H_1558
240 HB_444_HD HD M 5856_VC_H_1567
241 HB_457_HD HD M 5896_VC_H_1570
242 HB_466_HD HD M 5910_PF_H_1572
243 HB_478_HD HD M 5941_CR_H_1583
244 HB_487_HD HD F 5964_VC_H_1597
245 HB_511_HD HD M 6019_PF_H_2198
246 HB_513_HD HD F 6024_VC_H_1612
247 HB_515_HD HD F 6028_CR_H_1613
248 HB_518_HD HD M 6033_VC_H_1618
249 HB_522_HD HD M 6037_PF_H_1626
250 HB_527_HD HD F 6047_VC_H_1639
251 HB_528_HD HD M 6051_PF_H_1641
252 HB_530_HD HD M 6054_VC_H_1648
253 HB_537_HD HD F 6071_PF_H_1653
254 HB_549_HD HD M 6119_CR_H_1670
255 HB_593_HD HD NA 6219_CR_H_2567
256 HB_610_HD HD NA 6275_PF_H_1692
257 HB_616_HD HD F 6284_CR_H_1694
258 HB_626_HD HD M 6315_VC_H_1702
259 HB_639_HD HD F 6344_CR_H_1703
260 HB_649_HD HD F 6382_CR_H_1709
261 HB_661_HD HD M 6408_VC_H_1714
262 HB_682_HD HD M 6467_PF_H_1725
263 HB_683_HD HD M 6472_VC_H_1729
264 HB_691_HD HD F 6493_VC_H_1732
265 HB_692_HD HD M 6495_CR_H_1733
266 HB_707_HD HD M 6535_PF_H_1737
267 HB_709_HD HD F 6539_CR_H_1739
268 HB_725_HD HD M 6572_PF_H_1746
269 HB_732_HD HD F 6584_VC_H_1750
270 HB_734_HD HD F 6587_CR_H_1751
271 HB_748_HD HD NA 6615_VC_H_2315
272 HB_750_HD HD NA 6628_PF_H_2326
273 HB_758_HD HD NA 6643_VC_H_2602
274 HB_760_HD HD M 6646_PF_H_1761
275 HB_762_HD HD M 6650_VC_H_1765
276 HB_766_HD HD M 6658_VC_H_1768
277 HB_768_HD HD NA 6663_VC_H_1771
278 HB_769_HD HD M 6666_VC_H_1774
279 HB_774_HD HD NA 6689_PF_H_2344
280 HB_778_HD HD NA 6696_PF_H_2356
281 HB_780_HD HD NA 6704_PF_H_2362
282 HB_790_HD HD NA 6788_PF_H_2389
283 HB_800_HD HD NA 6807_PF_H_2419
284 HB_802_HD HD NA 6811_PF_H_2425
285 HB_045_AD AD NA 3734_CR_A_0122
286 HB_048_AD AD NA 3791_CR_A_0128
287 HB_053_AD AD NA 3877_CR_A_0134
288 HB_055_AD AD NA 3893_VC_A_0142
289 HB_068_AD AD NA 4349_VC_A_0148
290 HB_082_AD AD NA 4712_CR_A_0309
291 HB_085_AD AD NA 4726_VC_A_0311
292 HB_087_AD AD NA 4730_CR_A_0315
293 HB_089_AD AD NA 4733_VC_A_0320
294 HB_093_AD AD NA 4749_VC_A_0323
295 HB_095_AD AD NA 4759_CR_A_0327
296 HB_097_AD AD NA 4773_CR_A_0866
297 HB_099_AD AD NA 4785_VC_A_0332
298 HB_100_AD AD NA 4795_VC_A_0335
299 HB_103_AD AD NA 4811_VC_A_0341
300 HB_104_AD AD NA 4813_CR_A_0345
301 HB_112_AD AD NA 4842_VC_A_0870
302 HB_113_AD AD NA 4850_CR_A_0351
303 HB_114_AD AD NA 4852_CR_A_0354
304 HB_117_AD AD NA 4868_VC_A_0874
305 HB_122_AD AD NA 4904_CR_A_1132
306 HB_123_AD AD NA 4905_VC_A_0884
307 HB_124_AD AD NA 4916_VC_A_0886
308 HB_125_AD AD NA 4917_CR_A_0360
309 HB_126_AD AD NA 4921_VC_A_0362
310 HB_128_AD AD NA 4936_CR_A_0369
311 HB_130_AD AD NA 4939_VC_A_0888
312 HB_131_AD AD NA 4944_CR_A_0889
313 HB_132_AD AD NA 4946_CR_A_0372
314 HB_134_AD AD NA 4951_CR_A_0891
315 HB_135_AD AD NA 4953_VC_A_0893
316 HB_136_AD AD NA 4965_VC_A_0160
317 HB_137_AD AD NA 4966_VC_A_0374
318 HB_138_AD AD NA 4969_VC_A_0895
319 HB_140_AD AD NA 4993_CR_A_0896
320 HB_146_AD AD NA 5018_CR_A_0384
321 HB_148_AD AD NA 5022_VC_A_0386
322 HB_150_AD AD NA 5031_VC_A_0392
323 HB_151_AD AD NA 5033_CR_A_0396
324 HB_154_AD AD NA 5048_VC_A_1321
325 HB_155_AD AD NA 5056_VC_A_0398
326 HB_156_AD AD NA 5057_VC_A_0163
327 HB_157_AD AD NA 5059_VC_A_0401
328 HB_158_AD AD NA 5061_PF_A_2612
329 HB_160_AD AD NA 5064_PF_A_2615
330 HB_165_AD AD NA 5092_CR_A_0899
331 HB_168_AD AD NA 5097_VC_A_0407
332 HB_170_AD AD NA 5101_VC_A_0410
333 HB_174_AD AD NA 5124_PF_A_1343
334 HB_179_AD AD NA 5145_VC_A_1351
335 HB_181_AD AD NA 5152_CR_A_0414
336 HB_184_AD AD NA 5166_VC_A_1354
337 HB_194_AD AD NA 5193_VC_A_1360
338 HB_197_AD AD NA 5202_CR_A_1368
339 HB_199_AD AD NA 5205_VC_A_0166
340 HB_200_AD AD NA 5210_VC_A_0905
341 HB_205_AD AD NA 5235_VC_A_0419
342 HB_208_AD AD NA 5249_VC_A_0422
343 HB_209_AD AD NA 5252_VC_A_0907
344 HB_211_AD AD NA 5257_VC_A_0169
345 HB_216_AD AD NA 5272_VC_A_0425
346 HB_219_AD AD NA 5279_CR_A_0147
347 HB_221_AD AD NA 5283_VC_A_0145
348 HB_222_AD AD NA 5285_VC_A_0141
349 HB_224_AD AD NA 5288_VC_A_0428
350 HB_230_AD AD NA 5301_VC_A_0174
351 HB_231_AD AD NA 5305_VC_A_1384
352 HB_232_AD AD NA 5310_CR_A_0176
353 HB_234_AD AD NA 5313_PF_A_2618
354 HB_236_AD AD NA 5317_PF_A_2624
355 HB_238_AD AD NA 5322_CR_A_2632
356 HB_240_AD AD NA 5325_VC_A_0137
357 HB_244_AD AD NA 5337_VC_A_1387
358 HB_245_AD AD NA 5339_VC_A_0181
359 HB_250_AD AD NA 5346_VC_A_1393
360 HB_251_AD AD NA 5350_VC_A_0184
361 HB_252_AD AD NA 5355_VC_A_0133
362 HB_253_AD AD NA 5359_CR_A_1395
363 HB_258_AD AD NA 5370_PF_A_1400
364 HB_259_AD AD NA 5371_PF_A_2636
365 HB_260_AD AD NA 5375_VC_A_0188
366 HB_263_AD AD NA 5381_VC_A_0022
367 HB_265_AD AD NA 5385_VC_A_1402
368 HB_267_AD AD NA 5389_VC_A_0928
369 HB_268_AD AD NA 5390_CR_A_0151
370 HB_273_AD AD NA 5400_PF_A_2645
371 HB_274_AD AD NA 5401_VC_A_0931
372 HB_275_AD AD NA 5404_PF_A_2648
373 HB_276_AD AD NA 5406_VC_A_0933
374 HB_277_AD AD NA 5407_PF_A_2651
375 HB_280_AD AD NA 5412_VC_A_0935
376 HB_281_AD AD NA 5413_PF_A_2657
377 HB_283_AD AD NA 5419_VC_A_0937
378 HB_284_AD AD NA 5420_VC_A_0939
379 HB_285_AD AD NA 5421_CR_A_0432
380 HB_286_AD AD NA 5423_PF_A_2660
381 HB_288_AD AD NA 5425_PF_A_2666
382 HB_289_AD AD NA 5426_VC_A_1405
383 HB_290_AD AD NA 5433_VC_A_0434
384 HB_296_AD AD NA 5456_PF_A_2675
385 HB_299_AD AD NA 5461_VC_A_0192
386 HB_302_AD AD NA 5465_PF_A_2678
387 HB_303_AD AD NA 5469_VC_A_1417
388 HB_305_AD AD NA 5479_PF_A_1421
389 HB_306_AD AD NA 5480_VC_A_0437
390 HB_307_AD AD NA 5482_VC_A_0028
391 HB_308_AD AD NA 5483_VC_A_0941
392 HB_309_AD AD NA 5487_CR_A_0441
393 HB_310_AD AD NA 5488_CR_A_0194
394 HB_312_AD AD NA 5500_VC_A_0198
395 HB_313_AD AD NA 5502_PF_A_2684
396 HB_315_AD AD NA 5513_PF_A_2687
397 HB_316_AD AD NA 5516_PF_A_2690
398 HB_317_AD AD NA 5517_PF_A_2693
399 HB_318_AD AD NA 5518_CR_A_0030
400 HB_319_AD AD NA 5519_CR_A_2695
401 HB_320_AD AD NA 5520_PF_A_2699
402 HB_322_AD AD NA 5527_VC_A_0945
403 HB_325_AD AD NA 5532_PF_A_2702
404 HB_328_AD AD NA 5541_PF_A_2705
405 HB_330_AD AD NA 5544_VC_A_0201
406 HB_334_AD AD NA 5554_VC_A_0452
407 HB_335_AD AD NA 5557_VC_A_0950
408 HB_337_AD AD NA 5560_VC_A_0204
409 HB_342_AD AD NA 5571_PF_A_1430
410 HB_345_AD AD NA 5583_PF_A_2708
411 HB_347_AD AD NA 5589_PF_A_2714
412 HB_349_AD AD NA 5592_PF_A_2717
413 HB_352_AD AD NA 5604_VC_A_0037
414 HB_353_AD AD NA 5607_PF_A_2723
415 HB_356_AD AD NA 5615_VC_A_0041
416 HB_357_AD AD NA 5616_CR_A_0127
417 HB_358_AD AD NA 5617_CR_A_0456
418 HB_359_AD AD NA 5618_CR_A_0044
419 HB_362_AD AD NA 5625_CR_A_2495
420 HB_363_AD AD NA 5626_CR_A_2498
421 HB_364_AD AD NA 5629_CR_A_0390
422 HB_369_AD AD NA 5643_VC_A_1143
423 HB_373_AD AD NA 5654_VC_A_0047
424 HB_375_AD AD NA 5660_CR_A_0462
425 HB_376_AD AD NA 5661_VC_A_0464
426 HB_377_AD AD NA 5667_VC_A_2509
427 HB_378_AD AD NA 5668_VC_A_1438
428 HB_383_AD AD NA 5686_CR_A_2728
429 HB_386_AD AD NA 5695_VC_A_0953
430 HB_389_AD AD NA 5700_VC_A_2514
431 HB_391_AD AD NA 5705_CR_A_0474
432 HB_392_AD AD NA 5706_VC_A_0476
433 HB_394_AD AD NA 5713_VC_A_0479
434 HB_397_AD AD NA 5721_CR_A_0210
435 HB_404_AD AD NA 5735_CR_A_0489
436 HB_406_AD AD NA 5744_CR_A_0960
437 HB_409_AD AD NA 5749_CR_A_0159
438 HB_410_AD AD NA 5751_CR_A_2518
439 HB_411_AD AD NA 5755_CR_A_2731
440 HB_413_AD AD NA 5766_VC_A_0214
441 HB_419_AD AD NA 5790_VC_A_0217
442 HB_420_AD AD NA 5796_CR_A_0964
443 HB_428_AD AD NA 5811_CR_A_2524
444 HB_429_AD AD NA 5819_CR_A_2527
445 HB_430_AD AD NA 5822_CR_A_2530
446 HB_434_AD AD NA 5828_CR_A_2533
447 HB_435_AD AD NA 5831_CR_A_0222
448 HB_437_AD AD NA 5839_CR_A_2539
449 HB_438_AD AD NA 5843_CR_A_0227
450 HB_439_AD AD NA 5845_CR_A_0230
451 HB_441_AD AD NA 5849_CR_A_0233
452 HB_442_AD AD NA 5850_CR_A_0495
453 HB_445_AD AD NA 5858_CR_A_0969
454 HB_448_AD AD NA 5864_CR_A_0974
455 HB_451_AD AD NA 5871_CR_A_2542
456 HB_454_AD AD NA 5879_CR_A_2545
457 HB_455_AD AD NA 5887_CR_A_0976_Bis
458 HB_459_AD AD NA 5898_CR_A_2548
459 HB_460_AD AD NA 5900_VC_A_0237
460 HB_461_AD AD NA 5901_CR_A_0239
461 HB_469_AD AD NA 5914_CR_A_2554
462 HB_471_AD AD NA 5922_VC_A_0246
463 HB_473_AD AD NA 5927_CR_A_2560
464 HB_474_AD AD NA 5933_VC_A_1071
465 HB_477_AD AD NA 5939_CR_A_1151
466 HB_479_AD AD NA 5945_VC_A_0983
467 HB_484_AD AD NA 5956_CR_A_0123
468 HB_489_AD AD NA 5968_VC_A_1075
469 HB_491_AD AD NA 5971_CR_A_0119
470 HB_492_AD AD NA 5972_VC_A_0251
471 HB_494_AD AD NA 5979_CR_A_0115
472 HB_498_AD AD NA 5988_VC_A_0503
473 HB_502_AD AD NA 5994_PF_A_1605
474 HB_503_AD AD NA 5995_CR_A_2563
475 HB_510_AD AD NA 6017_CR_A_0048
476 HB_514_AD AD NA 6025_VC_A_0506
477 HB_517_AD AD NA 6031_VC_A_0258
478 HB_520_AD AD NA 6035_VC_A_1621
479 HB_523_AD AD NA 6038_VC_A_0261
480 HB_524_AD AD NA 6042_VC_A_1156
481 HB_525_AD AD NA 6044_VC_A_0264
482 HB_531_AD AD NA 6056_CR_A_0999
483 HB_533_AD AD NA 6061_PF_A_1650
484 HB_534_AD AD NA 6066_VC_A_0270
485 HB_535_AD AD NA 6067_PF_A_1452
486 HB_536_AD AD NA 6068_VC_A_0273
487 HB_545_AD AD NA 6102_CR_A_1661
488 HB_546_AD AD NA 6107_CR_A_0055
489 HB_550_AD AD NA 6120_VC_A_0058
490 HB_552_AD AD NA 6126_VC_A_1675
491 HB_553_AD AD NA 6129_PF_A_0274
492 HB_554_AD AD NA 6130_VC_A_1678
493 HB_555_AD AD NA 6131_CR_A_0510
494 HB_556_AD AD NA 6132_CR_A_0513
495 HB_558_AD AD NA 6137_VC_A_1681
496 HB_564_AD AD NA 6153_VC_A_1465
497 HB_565_AD AD NA 6154_VC_A_1468
498 HB_566_AD AD NA 6157_VC_A_0062
499 HB_568_AD AD NA 6164_CR_A_1005
500 HB_571_AD AD NA 6171_CR_A_0065
501 HB_573_AD AD NA 6174_VC_A_0068
502 HB_576_AD AD NA 6180_CR_A_0281
503 HB_583_AD AD NA 6194_VC_A_0071
504 HB_585_AD AD NA 6198_VC_A_0073
505 HB_590_AD AD NA 6215_VC_A_0518
506 HB_591_AD AD NA 6216_VC_A_1476
507 HB_592_AD AD NA 6218_CR_A_0522
508 HB_594_AD AD NA 6223_VC_A_0288
509 HB_596_AD AD NA 6226_CR_A_0076
510 HB_597_AD AD NA 6227_VC_A_0080
511 HB_598_AD AD NA 6231_VC_A_1479
512 HB_605_AD AD NA 6261_VC_A_0084
513 HB_608_AD AD NA 6268_CR_A_0525
514 HB_611_AD AD NA 6279_VC_A_0089
515 HB_612_AD AD NA 6280_VC_A_0091
516 HB_613_AD AD NA 6281_CR_A_0528
517 HB_621_AD AD NA 6308_VC_A_1503
518 HB_623_AD AD NA 6311_CR_A_0531
519 HB_624_AD AD NA 6312_CR_A_0534
520 HB_630_AD AD NA 6324_PF_A_1514
521 HB_633_AD AD NA 6332_VC_A_1518
522 HB_634_AD AD NA 6335_VC_A_0536
523 HB_635_AD AD NA 6336_CR_A_0290
524 HB_636_AD AD NA 6338_VC_A_0539
525 HB_642_AD AD NA 6358_VC_A_0545
526 HB_652_AD AD NA 6387_VC_A_0093
527 HB_657_AD AD NA 6394_VC_A_0551
528 HB_664_AD AD NA 6416_VC_A_1095
529 HB_666_AD AD NA 6422_CR_A_0555
530 HB_669_AD AD NA 6431_VC_A_0294
531 HB_674_AD AD NA 6449_VC_A_1183
532 HB_680_AD AD NA 6458_CR_A_2570
533 HB_685_AD AD NA 6481_VC_A_0560
534 HB_690_AD AD NA 6489_CR_A_0100
535 HB_696_AD AD NA 6511_VC_A_1119
536 HB_698_AD AD NA 6515_CR_A_0564
537 HB_699_AD AD NA 6518_VC_A_0103
538 HB_703_AD AD NA 6523_VC_A_0107
539 HB_704_AD AD NA 6530_VC_A_0112
540 HB_706_AD AD NA 6534_VC_A_0306
541 HB_712_AD AD NA 6546_PF_A_1194
542 HB_713_AD AD NA 6548_PF_A_1541
543 HB_715_AD AD NA 6550_VC_A_1201
544 HB_718_AD AD NA 6554_PF_A_1203
545 HB_720_AD AD NA 6559_PF_A_2287
546 HB_722_AD AD NA 6561_CR_A_2582
547 HB_723_AD AD NA 6562_PF_A_2290
548 HB_724_AD AD NA 6564_CR_A_2585
549 HB_727_AD AD NA 6575_CR_A_2298
550 HB_728_AD AD NA 6577_PF_A_2299
551 HB_729_AD AD NA 6578_PF_A_2302
552 HB_731_AD AD NA 6582_VC_A_1207
553 HB_733_AD AD NA 6585_VC_A_1210
554 HB_736_AD AD NA 6590_PF_A_1215
555 HB_743_AD AD NA 6603_PF_A_1448
556 HB_745_AD AD NA 6610_PF_A_1227
557 HB_746_AD AD NA 6612_PF_A_2308
558 HB_749_AD AD NA 6617_VC_A_2587
559 HB_751_AD AD NA 6629_VC_A_2330
560 HB_752_AD AD NA 6630_VC_A_2590
561 HB_753_AD AD NA 6632_PF_A_2332
562 HB_754_AD AD NA 6637_VC_A_2596
563 HB_755_AD AD NA 6638_VC_A_2599
564 HB_756_AD AD NA 6639_VC_A_2336
565 HB_757_AD AD NA 6641_PF_A_2338
566 HB_763_AD AD NA 6654_VC_A_1237
567 HB_773_AD AD NA 6681_VC_A_1252
568 HB_775_AD AD NA 6693_VC_A_2348
569 HB_776_AD AD NA 6694_VC_A_2351
570 HB_777_AD AD NA 6695_PF_A_2353
571 HB_779_AD AD NA 6699_PF_A_2359
572 HB_781_AD AD NA 6708_VC_A_2366
573 HB_782_AD AD NA 6776_PF_A_2607
574 HB_783_AD AD NA 6778_PF_A_2368
575 HB_784_AD AD NA 6779_PF_A_2371
576 HB_785_AD AD NA 6780_PF_A_2374
577 HB_786_AD AD NA 6782_PF_A_2377
578 HB_787_AD AD NA 6784_PF_A_2380
579 HB_788_AD AD NA 6785_CR_A_2385
580 HB_789_AD AD NA 6787_CR_A_2388
581 HB_791_AD AD NA 6790_PF_A_2392
582 HB_792_AD AD NA 6791_PF_A_2395
583 HB_793_AD AD NA 6793_PF_A_2398
584 HB_794_AD AD NA 6794_PF_A_2401
585 HB_795_AD AD NA 6797_PF_A_2404
586 HB_796_AD AD NA 6798_PF_A_2407
587 HB_797_AD AD NA 6799_VC_A_2411
588 HB_798_AD AD NA 6801_VC_A_2414
589 HB_799_AD AD NA 6803_VC_A_2417
590 HB_801_AD AD NA 6809_PF_A_2422
591 HB_803_AD AD NA 6818_CR_A_2430

About tissue

See PMID: 25080494

About platform

See PMID: 25080494

About data processing

See PMID: 25080494


See PMID: 25080494


Narayanan M, Huynh JL, Wang K, Yang X, Yoo S, McElwee J, Zhang B, Zhang C, Lamb JR, Xie T, Suver C, Molony C, Melquist S, Johnson AD, Fan G, Stone DJ, Schadt EE, Casaccia P, Emilsson V, Zhu J

Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases.

Mol Syst Biol. 2014 Jul 30;10:743. doi: 10.15252/msb.20145304.

PMID: 25080494


The Harvard Brain dataset was contributed by Merck Pharmaceutical through the Sage Bionetworks Repository. The tissues were provided by Harvard Brain Tissue Resource Center which is supported in part by PHS grant R24 MH068855 (http://www.brainbank.mclean.org/).


Species: Human
Tissue: Brain visual cortex,Brain cerebellum,Brain prefrontal cortex
Disease: Neurological Disease
Investigator: Francine Benes/ Eric Schadt
Institution: Harvard Brain Tissue Resource Center/ Merck Research Laboratories
Approximate Number Subjects: 803