MDC/CAS/UCL Liver 230v2 (Dec08) RMA

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Genome-wide co-expression analysis in multiple tissues.

And see closely associate set of papers:

  1. Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease.
  2. Heritability and tissue specificity of expression quantitative trait loci.
  3. Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass.
  4. New insights into the genetic control of gene expression using a Bayesian multi-tissue approach.
  5. The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance.
  6. A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.
  7. Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat.
  8. Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans.

About platform

Affymetrix 230Av2 GeneChip: Expression data were generated using the Affymetrix 230Av2 array (GEO_GPL341). The chromosomal locations of probe sets were determined by BLAT analysis of concatenated probe sequences using the Rat Genome Sequencing Consortium assembly.


Grieve IC1, Dickens NJ, Pravenec M, Kren V, Hubner N, Cook SA, Aitman TJ, Petretto E, Mangion J. Author information 1MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London, United Kingdom.


PLoS One. 2008;3(12):e4033. doi: 10.1371/journal.pone.0004033. Epub 2008 Dec 29.


This work was supported with funds to TJA by the MRC Clinical Sciences Centre, the British Heart Foundation, and the Wellcome Trust Cardiovascular Functional Genomics Initiative; to NH from the German Ministry for Science and Education (National Genome Research Network); to MP and Vladimir Kren from the Grant Agency of the Czech Republic; to MP and TJA from the Wellcome Trust Collaborative Research Initiative grant, to Theodore W Kurtz from the NIH, to TWK and MP from a Fogarty International Research Collaboration Award. Microarrays were a generous donation of Affymetrix Inc. Michal Pravenec thanks the Howard Hughes Medical Institute for its support to him as an international research scholar.