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Summary
The purpose of this experiment was to determine the expression traits in animals from F2 intercross of inbred strains C57BL/6J, C3H/HeJ. (N=309, 164 males and 145 females).
Experiment design
Liver from 302 F2 female and male mice were generated by intercrossing F1 mice. Mice were fed chow diet containing 4% fat (Ralston-Purina Co., St. Louis, MO) until 8 weeks of age and then were placed on a high-fat "Western" diet containing 42% fat and 0.15% cholesterol (Teklad 88137, Harlan Teklad, Madison WI) for 12 weeks. At 20 weeks mice were sacrificed, after a 12-hour fast liver tissues were dissected and flash frozen in LN2 and stored at -80°C. Keywords=Genetics of Gene Expression Keywords Keywords=C57B1/J6 Keywords=C3H/HeJ
Citation
- Orozco LD, Cokus SJ, Ghazalpour A, Ingram-Drake L et al. Copy number variation influences gene expression and metabolic traits in mice. Hum Mol Genet 2009 Nov 1;18(21):4118-29. PMID: 19648292
- van Nas A, Ingram-Drake L, Sinsheimer JS, Wang SS et al. Expression quantitative trait loci: replication, tissue- and sex-specificity in mice. Genetics2010 Jul;185(3):1059-68. PMID: 20439777