| Download datasets and supplementary data files |
|---|
Summary
Cg.5XFAD females (MMRRC Stock No #34848-JAX) were bred to males from BXD strains. The resulting F1 progeny were monitored throughout their lifepan to evaluate the effect of genetic background on cognitive and pathological traits. Samples here come from various Ntg-BXD lines at either 6 or 14 months of age. An earlier dataset of similar design (plus Non-transgenic littermates) was deposited as GSE101144. AD littermates of mice sampled here will be deposited as a separate GEO series. GEO Series GSE119408
Experiment design
71 Ntg samples. For final by-strain analysis, samples were averaged into strain/age/genotype/sex groups (For example, all D2 6mo 5XFAD males were averaged for final by-strain analysis)
About platform
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Contributors
Citation
- Dunn AR, Hadad N, Neuner SM, Zhang JG et al. Identifying Mechanisms of Normal Cognitive Aging Using a Novel Mouse Genetic Reference Panel. Front Cell Dev Biol 2020;8:562662. PMID: 33042997
- Gurdon B, Yates SC, Csucs G, Groeneboom NE et al. Detecting the effect of genetic diversity on brain composition in an Alzheimer's disease mouse model. Commun Biol 2024 May 20;7(1):605. PMID: 38769398