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Summary
Novel, systems-based approach to mouse genetics.
Experiment design
Expression profiling by array.
Expression Profiles from 99 strains of inbred and recombinant inbred mice. Most assayed in triplicate. Two of 288 chips were excluded from the final analysis due to low QC scores.
About cases
For complete information please refer to Bennett BJ, Farber CR, Orozco L, Kang HM, Ghazalpour A, Siemers N, Neubauer M, Neuhaus I, Yordanova R, Guan B, Truong A, Yang WP, He A, Kayne P, Gargalovic P, Kirchgessner T, Pan C, Castellani LW, Kostem E, Furlotte N, Drake TA, Eskin E, Lusis AJ (2010) A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Research 20:281-90 PMID: 20054062
About tissue
Hybrid Mouse diversity Panel Liver Expression Profile
About platform
Platform GPL8759 [HT_MG-430A] Affymetrix HT Mouse Genome 430A Array
The probe sets were selected from sequences derived from GenBank®, dbEST and RefSeq. The sequence clusters were created from the UniGene database (Build 107, June 2002) and then refined by analysis and comparison with the publicly available draft assembly of the mouse genome from the Whitehead Institute Center for Genome Research (MSCG, April 2002).
Oligonucleotide probes complementary to each corresponding sequence are synthesized in situ on the array. Eleven pairs of oligonucleotide probes, including a perfect match and mismatch probe, are used to measure the level of transcription of each sequence represented on the GeneChip® HT Mouse Genome 430 Array Plate Set.
About data processing
For complete information please refer to A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Res 2010 Feb;20(2):281-90. PMID: 20054062
Contributors
Citation
Bennett BJ, Farber CR, Orozco L, Kang HM et al. A high-resolution association mapping panel for the dissection of complex traits in mice. Genome Res 2010 Feb;20(2):281-90. PMID: 20054062
Acknowledgment
Bennett BJ, Ghazalpour A
Notes
Raw data provided as supplementary file at GEO Series GSE16780