UCLA BHF2 Liver Male mlratio

Summary

The (C57BL/6J X C3H/HeJ)F2 intercross consists of 334 animals of both sexes. All are ApoE null and received a high fat Western diet from 8-24 weeks of age.

Experiment design

Livers from 311 F2 female and male mice (animals fed a high fat "Western" diet from 8-24 weeks of age.) derived from C57BL/6J and C3H/HeJ parental strains with both on ApoE null backgrounds. All samples were compared to a common pool created from equal portions of RNA from each of the samples. Keywords=Genetics of Gene Expression Keywords=C57BL/6J Keywords=C3H/HeJ

Citation

• Wang S, Yehya N, Schadt EE, Wang H et al. Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet 2006 Feb;2(2):e15. PMID: 16462940
• Yang X, Schadt EE, Wang S, Wang H et al. Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res 2006 Aug;16(8):995-1004. PMID: 16825664
• Ghazalpour A, Doss S, Zhang B, Wang S et al. Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet 2006 Aug 18;2(8):e130. PMID: 16934000
• Chen Y, Zhu J, Lum PY, Yang X et al. Variations in DNA elucidate molecular networks that cause disease. Nature 2008 Mar 27;452(7186):429-35. PMID: 18344982
• Wu S, Mar-Heyming R, Dugum EZ, Kolaitis NA et al. Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice. Hum Mol Genet2010 Feb 15;19(4):597-608. PMID: 19995791
• van Nas A, Ingram-Drake L, Sinsheimer JS, Wang SS et al. Expression quantitative trait loci: replication, tissue- and sex-specificity in mice. Genetics2010 Jul;185(3):1059-68. PMID: 20439777

Specifics of this data set

Males only