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Summary
Female C57BL/6J mice hemizygous for the 5XFAD transgene (MMRRC Stock No #34848-JAX) were bred to males from BXD strains, which do not carry the 5XFAD transgene. The resulting F1 progeny were monitored throughout their lifespan to evaluate the effect of genetic background on cognitive and pathological traits. All of the mice were fear conditioned and sacrificed within 30 minutes of testing. On the sample records, the characteristics: age field provides the age at which fear conditioning, sacrifice, and tissue collection occurred. Samples here come from various AD-BXD lines and their non-transgenic (Ntg) littermate counterparts at either 6 or 14 months of age. GEO Series GSE101144
Experiment design
133 samples, 64 Ntg and 69 AD. For final by-strain analysis, samples were averaged into strain/age/genotype/sex groups (For example, all D2 6mo 5XFAD males were averaged for final by-strain analysis)
About platform
| GPL17021 | Illumina HiSeq 2500 (Mus musculus) |
Contributors
Citation
- Neuner SM, Heuer SE, Huentelman MJ, O'Connell KMS et al. Harnessing Genetic Complexity to Enhance Translatability of Alzheimer's Disease Mouse Models: A Path toward Precision Medicine. Neuron 2019 Feb 6;101(3):399-411.e5. PMID: 30595332
- Dunn AR, Hadad N, Neuner SM, Zhang JG et al. Identifying Mechanisms of Normal Cognitive Aging Using a Novel Mouse Genetic Reference Panel. Front Cell Dev Biol 2020;8:562662. PMID: 33042997
- Gurdon B, Yates SC, Csucs G, Groeneboom NE et al. Detecting the effect of genetic diversity on brain composition in an Alzheimer's disease mouse model. Commun Biol 2024 May 20;7(1):605. PMID: 38769398